A 3-part illustration including supportive architectural pillars, radioligand molecules binding to cancer cells, and a multidisciplinary care team with a patient.

Foundations of theranostics

Radioligand therapy (RLT) and radioligand imaging (RLI) offer a novel, theranostic approach to targeting and treating certain types of cancer.¹ This section of the Novartis RLT Institute is designed to help health care professionals (HCPs) understand the basic scientific foundations of RLT. By focusing on the science, we aim to demystify radiation and safety concerns and build confidence in offering patients this approach to precision medicine in cancer.

Radiation safety fundamentals

Safety equipment

Radiation detection equipment

There are many different types of equipment used to detect radiation, including^2,3:

Dose calibrator

Measures the activity of RLI and RLT doses to ensure accurate and safe administration

Personal dosimeter

Monitors radiation exposure for staff, ensuring levels remain within safety limits

Survey meter

Detects ambient radiation and contamination on surfaces, equipment, or personnel

For ambient radiation and contamination surveying, the area is typically surveyed with a Geiger counter or scintillation survey meter. In the case of contamination, removable contamination can be detected and measured by conducting a wipe test of the surface, counted in an appropriate instrument, such as a liquid scintillation counter.⁴